NFL Week 2 2025: Matchups, Picks, and Bold Predictions

     After an eventful Week 1 of the 2025 NFL Season, the second week will kick off this Thursday. Before we get into the predictions for this past week, let’s take a look at my stats and predictions from week one. 

Week 1: 9-7 ; Avg Points Off per Team: 8.7 

3 Closest Perfect Games:

My Picks: KC 23 LAC 24, PHI 34 DAL 20, ARI 27 NO 10

Real Scores: KC 21 LAC 27, PHI 24 DAL 20, ARI 20 NO 13

(+3.5) Commanders (1-0) @ Packers (1-0) - Thursday Sept. 11th 8:15 PM ET | Prime Video

Two of the superstar young quarterbackers will clash on Thursday Night in Green Bay, as the Commanders take on the Packers. Washington's offseason acquisition Deebo Samuel showed out totaling 96 total yards along with a 19-yard rushing touchdown. Rookie 7th round running back Jacory Croskey-Merritt had 82 rushing yards and a six-yard rushing touchdown. As for Green Bay, their defense was able to hold the Detroit Lions to just 13 total points, with 7 of them coming with 55 seconds left in garbage time. Jordan Love threw two touchdown passes, as they took down their divisional rivals, 27-13. 

Standout Pick - Jordan Love OVER 34.5 Passing Attempts (+300)

Score Prediction

WSH 27 GB 31

(-5.5) Rams (1-0) @ Titans (0-1) - Sunday Sept. 14th 1:00 PM ET | CBS

The Los Angeles Rams will head into Tennessee to take on rookie QB Cam Ward and the Titans. The Rams defense were able to hold star QB CJ Stroud under 200 yards and picked him off, helping them squeak out with a 14-9 win over the Texans. Puka Nacua went off for 130 receiving yards on 10 catches. As for Tennessee, they were able to keep it competitive with the Broncos all the way down to the finish line. However, Ward was only able to complete 43% of his passes and threw for just 112 yards in his NFL debut. He also didn’t get protected well, being taken down 6 times. 

Standout Pick - Puka Nacua OVER 89.5 Receiving Yards (+135)

Score Prediction

LAR 34 TEN 17

(+3.5) Jaguars (1-0) @ Bengals (1-0) - Sunday Sept. 14th 1:00 PM ET | CBS

Joe Burrow and the Bengals finally captured a Week 1 victory, but it wasn’t exactly smooth sailing. Cincinnati’s QB Joe Burrow threw just 23 passes, for 113 yards through the air. They were able to pick off Browns QB Joe Flacco 2 times, and squeaked out with a 17-16 win. As for Jacksonville, they are coming off of a 26-10 victory over the Panthers. Just like the Bengals, the Jaguars picked off Bryce Young twice in the win. Their bread and butter was their rushing attack however, as Travis Etienne had 143 rushing yards, including breaking off one for 71 yards. 

Standout Pick - Ja’Marr Chase OVER 1.5 Receiving Touchdowns (+475)

Score Prediction

JAX 17 CIN 27

(+11.5) Browns (0-1) @ Ravens (0-1) - Sunday Sept. 14th 1:00 PM ET | CBS

The Cleveland Browns were able to stick with Cincinnati for their contest last weekend, they just couldn’t get the victory. As for Baltimore, they had a 15 point lead with under 4 minutes to go against the Buffalo Bills, and they blew it. Despite that, Derrick Henry rushed for just under 200 yards, and Lamar Jackson had a field day, accounting for 3 touchdowns, and 279 total yards of offense. 

Standout Pick - Ravens -18.5 (+230)

Score Prediction

CLE 10 BAL 41

(-6.5) Bills (1-0) @ Jets (0-1) - Sunday Sept. 14th 1:00 PM ET | CBS

The Buffalo Bills were dead in the water on Sunday Night, but they found their ways out. QB Josh Allen threw for a total 394 passing yards, with over 250 of them coming in just the 4th quarter alone. Backup kicker Matt Prater was able to nail a game-winning field goal, as the Bills took down Baltimore. As for New York, they also had a shootout, as their new QB Justin Fields balled out. The Jets lost by two (34-32), but Fields had 218 passing yards and added 48 on the ground. Fields also had three total touchdowns, with two of them coming on two and one yard rushes respectively. 

Standout Pick - Josh Allen OVER 299.5 Passing Yards (+450)

Score Prediction

BUF 33 NYJ 17

(+1.5) Patriots (0-1) @ Dolphins (0-1) - Sunday Sept. 14th 1:00 PM ET | CBS

The New England Patriots will travel down to Miami, to visit Tua and the Dolphins. The Dolphins lost 33-8 to the Colts this past week, as they let Daniel Jones look like a top QB in the NFL. As for New England, they didn’t fare much better, letting Geno Smith throw for 362 passing yards. These teams both need a victory, and I expect Miami to grab it. 

Standout Pick - Tua Tagovailoa OVER 1.5 Passing Touchdowns

Score Prediction

NE 17 MIA 23

(-4.5) 49ers (1-0) @ Saints (0-1) - Sunday Sept. 14th 1:00 PM ET | FOX

The San Francisco 49ers may be in danger right now, but they will need to find a way to battle through. George Kittle is on the IR (hamstring), and Brock Purdy (toe, shoulder) is doubtful, and may miss multiple weeks. As of now, Mac Jones is in line to make his first career start in the red and gold. As for New Orleans, they are led by Spencer Rattler, and they came up just short last week, falling 20-13 to the Arizona Cardinals. 

Standout Pick - Mac Jones OVER 199.5 Passing Yards (+120)

Score Prediction

SF 27 NO 16

(+5.5) Giants (0-1) @ Cowboys (0-1) - Sunday Sept. 14th 1:00 PM ET | FOX

“Russ will be the starter.” That is what Brian Daboll said regarding a QB change just one week into the season. The Giants fell to the Washington Commanders this past weekend, and it was ugly. As for Dallas, they were able to keep their game against the Eagles close, but Philadelphia started to pull away after the weather delay. 

Standout Pick - Russell Wilson UNDER 24.5 Rushing Yards (-110)

Score Prediction

NYG 13 DAL 20

(+6.5) Bears (0-1) @ Lions (0-1) - Sunday Sept. 14th 1:00 PM ET | FOX

The Chicago Bears head to Ford Field after blowing a sure fire win against the Minnesota Vikings. After having a 17-6 lead going into the fourth quarter, Minnesota scored two touchdowns in the span of 2:27 minutes of game time. They then tacked on another to go up 27-17. The Bears would salvage a touchdown, but would still fall 27-24. As for Detroit, their game wasn’t any better. They faced their divisional rivals the Packers, and got smashed 27-13. Jarred Goff threw 39 passes, and was taken down 4 times. I expect them to bounce back however, and take care of business at home. 

Standout Pick - Amon-Ra St. Brown OVER 0.5 Total Touchdowns (-120) 

Score Prediction

CHI 23 DET 27

(+2.5) Seahawks (0-1) @ Steelers (1-0) - Sunday Sept. 14th 1:00 PM ET | FOX

The Sam Darnold lead Seahawks didn’t start their year off the way they wanted to, but they can attempt to turn it around up north this week. Seattle fell 17-13 to the 49ers, and they didn’t get the performance out of their new quarterback. On the flip side, the Steelers got exactly what they wanted out of Aaron Rodgers,  as he 

Standout Pick - Aaron Rodgers OVER 1.5 Passing Touchdown (+140)

Score Prediction

SEA 16 PIT 24

(-1.5) Broncos (1-0) @ Colts (1-0) - Sunday Sept. 14th 4:05 PM ET | CBS

Bo Nix and the Broncos got an extremely ugly 13-12 victory over the Tennessee Titans this past Sunday. Now, they will travel to Indianapolis, to take on the undefeated Colts team. Daniel Jones came out of nowhere to look like one the best QBs in the league. Their defense also balled out, holding the Dolphins offense to just 8 points. 

Standout Pick - Daniel Jones OVER 224.5 Passing Yards (+155)

Score Prediction

DEN 19 IND 27

(+6.5) Panthers (0-1) @ Cardinals (1-0) - Sunday Sept. 14th 4:05 PM ET | CBS

Kyler Murray and the Arizona Cardinals are coming off of a hard fought win over the New Orleans Saints that came down to the wire. The Saints had a chance to tie it, but were unsuccessful, as the Cardinals took home the victory. As for Carolina, they got caught in the second weather delay of the weekend, and lost in Jacksonville 26-10. I think the Panthers will rebound, but a late game comeback helps the Cardinals secure the win. 

Standout Pick - Kyler Murray OVER 29.5 Rushing Yards (+125)

Score Prediction

CAR 26 ARI 28

(-1.5) Eagles (1-0) @ Chiefs (0-1) - Sunday Sept. 14th 4:25 PM ET | FOX

The Super Bowl rematch has arrived! The Kansas City Chiefs are coming  off of an opening game defeat, as they take on Jalen Hurts and the Eagles. Philadelphia DT Jalen Carter was ejected six seconds into the season for spitting on Dallas QB Dak Prescott. Despite this, the Eagles snuck out with a 24-20 win. As for Kansas City, they fell to the Chargers in Brazil. WR Xavier Worthy was taken out by Travis Kielce on the opening sequence of the game, and he didn’t return. It was an overall bad night for Kelce, as he totaled just 2 receptions for 47 receiving yards. 

Standout Pick - Saquon Barkley OVER 1.5 Total Touchdowns

Score Prediction

PHI 41 KC 38

(+3.5) Falcons (0-1) @ Vikings (1-0) - Sunday Sept. 14th 8:20 PM ET | NBC

The Minnesota Vikings were able to erase an 11 point deficit last week, and hand second-year QB JJ McCarthy his first career win in his only start thus far. It wasn’t that smooth for Atlanta however, as Michael Penix Jr. and the Falcons fell to the Buccaneers 23-20. However, Penix Jr. had an amazing performance, throwing for 298 passing yards, and adding 21 more on the ground. 

Standout Pick - Justin Jefferson OVER 0.5 Total Touchdowns (+110)

Score Prediction

ATL 20 MIN 24

(+2.5) Buccaneers (1-0) @ Texans (0-1) - Monday Sept. 15th 7:00 PM ET | ABC/ESPN

The Tampa Bay Buccaneers and Houston Texans will clash as the first of two games on a Monday Night doubleheader. The Texans fell to the Rams 14-9 last week, as they were unable to get the offense going. Ka’imi Fairbairn accounted for all of Houston’s points, as he put three field goals through the uprights. As for Tampa Bay, they were able to defeat Atlanta by 3 points. Rookie WR Emeka Egbuka had a nice performance, hauling in two receiving touchdowns in his debut. 

Standout Pick - Baker Mayfield OVER 1.5 Passing Touchdowns (+120)

Score Prediction

TB 34 HOU 20

(-3.5) Chargers (1-0) @ Raiders (1-0) - Monday Sept. 15th 10:00 PM ET | ESPN

The Los Angeles Chargers come back from Brazil after defeating the reigning AFC Champs 27-21. Justin Herbert had a nice performance, boasting over 300 passing yards, three touchdowns and a passer rating of 131.8. Las Vegas QB Geno Smith also threw for over 300 yards (362) en route to a 20-13 victory over the Patriots. Rookie running back Ashton Jeanty wasn’t spectacular however, rushing for just two yards per carry on 19 attempts. 

Standout Pick - Omarion Hampton OVER 69.5 Rushing Yards (+165)

Score Prediction

LAC 31 LV 23